SCHEMBL5136465

SCHEMBL5136465

Cc1ccc(F)cc1C1c2ccccc2CCN1CC(=O)N(Cc1ccccc1F)C1Cc2ccccc2C1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
C5AR1 P21730 1/20 0.52
OPRM1 P35372 2/20 0.38
HDAC8 Q9BY41 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
THRB P10828 1/20 0.36
HTR2A P28223 5/20 0.35
MAPT P10636 1/20 0.35
ALDH1A1 P00352 1/20 0.35
OPRK1 P41145 1/20 0.34
CHRM3 P20309 2/20 0.34
RORC P51449 1/20 0.34
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5137857 0.93 C5AR1 (0.52) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL6342639 0.92 C5AR1 (0.56) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL6259390 0.92 C5AR1 (0.56) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL5136056 0.92 C5AR1 (0.56) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL5136178 0.92 C5AR1 (0.51) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL5136870 0.91 C5AR1 (0.54) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL5137894 0.89 C5AR1 (0.49) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL6342543 0.88 C5AR1 (0.56) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL5136013 0.88 C5AR1 (0.56) C5AR1OPRM1HDAC8MEN1KMT2A
SCHEMBL5135005 0.88 C5AR1 (0.52) C5AR1OPRM1HDAC8MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6777422-B2 FOR TREATING A VARIETY OF INFLAMMATORY AND IMMUNE SYSTEM DISORDERS NEUROGEN CORP. 2004-08-17 US claimed
EP-1490044-A4 COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS NEUROGEN CORP (US) 2008-04-16 EP disclosed
US-20050158663-A1 Regenerative plate making and printing process, and plate making and printing apparatus MITSUBISHI HEAVY INDUSTRIES, LTD. (JP) 2005-07-21 US disclosed
US-6916830-B2 Substituted tetrahydroisoquinolines as C5a receptor modulators NEUROGEN CORPORATION (US) 2005-07-12 US disclosed
EP-1490044-A1 COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS NEUROGEN CORPORATION (US) 2004-12-29 EP disclosed
US-6777422-B2 FOR TREATING A VARIETY OF INFLAMMATORY AND IMMUNE SYSTEM DISORDERS NEUROGEN CORP. 2004-08-17 US disclosed
WO-2003084524-A1 COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS NEUROGEN CORPORATION (US) 2003-10-16 WO disclosed