Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648484 | 0.94 | C5AR1 (0.56) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL5135637 | 0.94 | C5AR1 (0.65) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL652163 | 0.93 | C5AR1 (0.64) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL649080 | 0.92 | C5AR1 (0.56) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL5135929 | 0.91 | C5AR1 (0.72) | C5AR1TSHRPPARGPPARALMNA | |
| SCHEMBL4767016 | 0.91 | C5AR1 (0.75) | C5AR1TSHRPPARGPPARALMNA | |
| SCHEMBL648929 | 0.91 | C5AR1 (0.55) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL5136520 | 0.91 | C5AR1 (0.61) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL651019 | 0.89 | C5AR1 (0.53) | C5AR1TSHRPPARGPPARASIRT2 | |
| SCHEMBL650916 | 0.89 | C5AR1 (0.58) | C5AR1TSHRPPARGPPARASIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |