Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Protocatechuic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.83 |
| ▸ | CA1 | P00915 | 2/20 | 0.83 |
| ▸ | CA2 | P00918 | 2/20 | 0.83 |
| ▸ | CA6 | P23280 | 2/20 | 0.83 |
| ▸ | CA9 | Q16790 | 2/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.83 |
| ▸ | GAA | P10253 | 1/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
| ▸ | CA4 | P22748 | 1/20 | 0.83 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.83 |
| ▸ | CA7 | P43166 | 1/20 | 0.83 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Protocatechuic Acid SCHEMBL2525247 | 0.93 | CA12 (0.86) | CA12CA1CA2CA6CA9 | |
| Terephthalic Acid SCHEMBL27943509 | 0.93 | CA12 (0.95) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL28487427 | 0.93 | CA12 (0.95) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL29350008 | 0.91 | CA12 (1.00) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL27815804 | 0.91 | CA12 (1.00) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL30030432 | 0.91 | CA12 (1.00) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL39435 | 0.91 | CA12 (1.00) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL27926677 | 0.89 | CA12 (0.79) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL23495982 | 0.89 | CA12 (0.95) | CA12CA1CA2CA6CA9 | |
| Protocatechuic Acid SCHEMBL2274950 | 0.89 | CA12 (0.95) | CA12CA1CA2CA6CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2003968-A2 | COMPOSITIONS AND METHODS TO ADD VALUE TO PLANT PRODUCTS, SO INCREASING THE COMMERCIAL QUALITY, RESISTANCE TO EXTERNAL FACTORS AND POLYPHENOL CONTENT THEREOF | Leschot Sanhueza, Andres Antonio (CL) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007110801-A2 | COMPOSITIONS AND METHODS TO ADD VALUE TO PLANT PORDUCTS, INCREASING THE COMMERCIAL QUALITY, RESISTANCE TO EXTERNAL FACTORS AND POLYPHENOL CONTENT THEREOF | LESCHOT SANHUEZA ANDRES ANTONI (CL) | 2007-10-04 | — | — | WO | disclosed |