Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.47 |
| ▸ | F2R | P25116 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 2/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768999 | 0.93 | C5AR1 (0.51) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5135680 | 0.91 | C5AR1 (0.47) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5136462 | 0.91 | C5AR1 (0.56) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5136006 | 0.91 | C5AR1 (0.46) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL14415541 | 0.90 | C5AR1 (0.52) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5136963 | 0.89 | C5AR1 (0.47) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5134878 | 0.88 | C5AR1 (0.55) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5147061 | 0.87 | C5AR1 (0.46) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5135932 | 0.87 | C5AR1 (0.46) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5178967 | 0.87 | C5AR1 (0.45) | C5AR1F2RHSP90AA1HSP90AB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |