Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | F2R | P25116 | 3/20 | 0.35 |
| ▸ | UBE2M | P61081 | 3/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135482 | 0.88 | HTR2A (0.43) | C5AR1F2RTP53SMN1; SMN2HTR2A | |
| SCHEMBL4766728 | 0.87 | C5AR1 (0.51) | C5AR1F2RUBE2MDCUN1D1SMN1; SMN2 | |
| SCHEMBL5135940 | 0.85 | C5AR1 (0.46) | C5AR1F2RUBE2MDCUN1D1TP53 | |
| SCHEMBL5135886 | 0.85 | C5AR1 (0.42) | C5AR1F2RTP53SMN1; SMN2HTR2A | |
| SCHEMBL5135741 | 0.84 | C5AR1 (0.48) | C5AR1F2RUBE2MDCUN1D1SMN1; SMN2 | |
| SCHEMBL5136612 | 0.83 | C5AR1 (0.45) | C5AR1F2RTP53SMN1; SMN2HTR2A | |
| SCHEMBL5136147 | 0.83 | C5AR1 (0.47) | C5AR1F2RUBE2MDCUN1D1SMN1; SMN2 | |
| SCHEMBL5147409 | 0.83 | C5AR1 (0.54) | C5AR1F2RTP53SMN1; SMN2HTR2A | |
| SCHEMBL5149996 | 0.83 | C5AR1 (0.49) | C5AR1F2RTP53SMN1; SMN2HTR2A | |
| SCHEMBL5136286 | 0.83 | HTR2A (0.48) | C5AR1TP53SMN1; SMN2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |