Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912837 | 0.98 | C5AR1 (0.55) | C5AR1PTGDR2SMN1; SMN2TDP1TSHR | |
| SCHEMBL5137517 | 0.97 | C5AR1 (0.50) | C5AR1PTGDR2SMN1; SMN2TDP1TSHR | |
| SCHEMBL5134857 | 0.94 | C5AR1 (0.60) | C5AR1SMN1; SMN2TDP1TSHRLMNA | |
| SCHEMBL5137292 | 0.94 | C5AR1 (0.46) | C5AR1PTGDR2SMN1; SMN2TDP1TSHR | |
| SCHEMBL5134695 | 0.94 | C5AR1 (0.47) | C5AR1PTGDR2SMN1; SMN2TDP1TSHR | |
| SCHEMBL647999 | 0.92 | C5AR1 (0.62) | C5AR1SMN1; SMN2TDP1TSHRLMNA | |
| SCHEMBL650295 | 0.92 | C5AR1 (0.48) | C5AR1PTGDR2TSHRLMNACYP2C8 | |
| SCHEMBL1912862 | 0.92 | C5AR1 (0.49) | C5AR1PTGDR2SMN1; SMN2TDP1TSHR | |
| SCHEMBL5135566 | 0.92 | C5AR1 (0.57) | C5AR1SMN1; SMN2TDP1TSHRLMNA | |
| SCHEMBL648765 | 0.92 | C5AR1 (0.47) | C5AR1PTGDR2SMN1; SMN2TDP1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |