Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.80 |
| ▸ | PDE4A | P27815 | 15/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909087 | 0.93 | BRAF (0.77) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4909140 | 0.93 | BRAF (0.77) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4926642 | 0.89 | BRAF (1.00) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908043 | 0.88 | BRAF (0.71) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4911905 | 0.86 | BRAF (0.91) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4909797 | 0.86 | BRAF (0.84) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281416 | 0.85 | BRAF (0.93) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908862 | 0.85 | BRAF (0.88) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907531 | 0.85 | BRAF (0.88) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4906957 | 0.83 | BRAF (0.81) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |