Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 12/20 | 0.88 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.88 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137813 | 1.00 | AVPR1A (0.88) | AVPR1AAVPR2POLBOXTRSIGMAR1 | |
| SCHEMBL4359530 | 0.94 | AVPR1A (1.00) | AVPR1AAVPR2POLBOXTRSPR | |
| SCHEMBL4355267 | 0.91 | AVPR1A (0.81) | AVPR1AAVPR2POLBOXTRSIGMAR1 | |
| SCHEMBL4355271 | 0.91 | AVPR1A (0.81) | AVPR1AAVPR2POLBOXTRSIGMAR1 | |
| SCHEMBL4357951 | 0.90 | AVPR1A (0.80) | AVPR1AAVPR2POLBOXTRSPR | |
| SCHEMBL4359406 | 0.89 | AVPR1A (0.84) | AVPR1AAVPR2POLBOXTRSIGMAR1 | |
| SCHEMBL4363164 | 0.88 | AVPR1A (0.82) | AVPR1AAVPR2POLBOXTRSIGMAR1 | |
| SCHEMBL4363166 | 0.88 | AVPR1A (0.82) | AVPR1AAVPR2POLBOXTRSIGMAR1 | |
| SCHEMBL4357898 | 0.88 | AVPR1A (0.85) | AVPR1AAVPR2POLBOXTRSPR | |
| SCHEMBL4362913 | 0.86 | AVPR1A (0.82) | AVPR1AAVPR2POLBOXTRSPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904477-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006688-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |