Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5072326 | 0.94 | C5AR1 (0.41) | C5AR1BCHEHDAC1ACHENR1D1 | |
| SCHEMBL4763715 | 0.88 | C5AR1 (0.46) | C5AR1BCHEHDAC1ACHEALDH1A1 | |
| SCHEMBL5137739 | 0.88 | C5AR1 (0.43) | C5AR1POLBABCC1ABCG2ALDH1A1 | |
| SCHEMBL5135644 | 0.88 | POLB (0.43) | C5AR1POLBBCHEHDAC1ABCC1 | |
| SCHEMBL5135268 | 0.87 | C5AR1 (0.42) | C5AR1BCHEHDAC1ACHEAVPR1B | |
| SCHEMBL651431 | 0.87 | C5AR1 (0.43) | C5AR1BCHEHDAC1ACHEALDH1A1 | |
| SCHEMBL5135294 | 0.86 | C5AR1 (0.44) | C5AR1BCHEHDAC1ACHEABCC1 | |
| SCHEMBL1913025 | 0.85 | C5AR1 (0.41) | C5AR1BCHEHDAC1ACHEALDH1A1 | |
| SCHEMBL5135713 | 0.84 | C5AR1 (0.44) | C5AR1HDAC1ABCC1ALDH1A1KDM4E | |
| SCHEMBL5137864 | 0.84 | C5AR1 (0.44) | C5AR1BCHEHDAC1ABCC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |