Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790400 | 0.79 | MAPT (0.39) | PARP1 | |
| SCHEMBL25138054 | 0.72 | PARP1 (0.41) | PARP1 | |
| SCHEMBL12828410 | 0.71 | PARP10 (0.39) | PARP1PARP10PARP11PDPK1 | |
| SCHEMBL14085223 | 0.71 | PARP1 (0.38) | PARP1PARP10PARP11PDPK1 | |
| SCHEMBL14085078 | 0.70 | PARP10 (0.41) | PARP1PARP10PARP11PDPK1PARP2 | |
| SCHEMBL12580789 | 0.70 | NPC1 (0.42) | — | |
| SCHEMBL832352 | 0.70 | PRKD3 (0.33) | PARP1 | |
| SCHEMBL31037184 | 0.70 | PARP1 (0.56) | PARP1 | |
| SCHEMBL6854090 | 0.70 | PARP1 (0.56) | PARP1 | |
| SCHEMBL743887 | 0.69 | HTR2A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154129-A1 | PHARMACEUTICAL COMPOSITIONS AND METHOD FOR TREATING, REDUCING, AMELIORATING, ALLEVIATING, OR PREVENTING DRY EYE | BAUSCH & LOMB INCORPORATED (US) | 2008-12-18 | — | — | WO | claimed |
| US-7915280-B2 | Compounds and their uses | EISAI INC. (US) | 2011-03-29 | — | — | US | disclosed |
| EP-1140936-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES | AGOURON PHARMACEUTICALS, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000042040-A1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES | AGOURON PHARMACEUTICALS, INC. (US) | 2000-07-20 | — | — | WO | disclosed |