Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.58 |
| ▸ | INSR | P06213 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | FRK | P42685 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138428 | 0.88 | IGF1R (0.47) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL402423 | 0.85 | IGF1R (0.79) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL5082145 | 0.82 | IGF1R (0.39) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL5139332 | 0.78 | IGF1R (0.57) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL399838 | 0.77 | IGF1R (0.58) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL401795 | 0.77 | IGF1R (0.66) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL5138538 | 0.76 | IGF1R (0.40) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL5137559 | 0.75 | IGF1R (0.45) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL5085578 | 0.75 | IGF1R (0.55) | IGF1RCYP3A4INSRKDREGFR | |
| SCHEMBL1683109 | 0.74 | IGF1R (0.71) | IGF1RCYP3A4INSRKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |