Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 5/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085254 | 0.92 | KDR (0.61) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5089551 | 0.92 | KDR (0.63) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5087029 | 0.89 | KDR (0.59) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5025516 | 0.88 | AURKA (0.66) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5016634 | 0.87 | AURKA (0.65) | KDRAURKBAURKAIRAK4HDAC3 | |
| Hydrochloric Acid SCHEMBL5022853 | 0.86 | KDR (0.69) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5016600 | 0.86 | KDR (0.59) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5089035 | 0.86 | KDR (0.60) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5094864 | 0.85 | KDR (0.59) | KDRAURKBAURKAIRAK4HDAC3 | |
| SCHEMBL5022442 | 0.85 | KDR (0.60) | KDRAURKBAURKAIRAK4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575966-B1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |