Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.53 |
| ▸ | EGFR | P00533 | 9/20 | 0.53 |
| ▸ | ABL1 | P00519 | 8/20 | 0.53 |
| ▸ | ABL2 | P42684 | 8/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 5/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | NPM1 | P06748 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399403 | 0.88 | SRC (0.71) | SRCEGFRABL1ABL2LCK | |
| Carbamic Acid SCHEMBL19244734 | 0.82 | EGFR (0.64) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL27890217 | 0.82 | SRC (0.49) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL28763777 | 0.81 | SRC (0.61) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL19244733 | 0.79 | SRC (0.60) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL402582 | 0.79 | SRC (0.61) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL397595 | 0.78 | SRC (0.61) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL14193039 | 0.78 | SRC (0.63) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL400625 | 0.78 | SRC (0.63) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL400624 | 0.78 | SRC (0.63) | SRCEGFRABL1ABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |