Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967121 | 0.95 | EGLN1 (0.54) | EGLN1EGLN2CTSK | |
| SCHEMBL966335 | 0.93 | EGLN1 (0.46) | EGLN1THRATHRB | |
| SCHEMBL5138824 | 0.87 | HDAC6 (0.37) | EGLN1EGLN2CTSK | |
| SCHEMBL1975510 | 0.77 | MAPT (0.55) | CTSK | |
| SCHEMBL1656039 | 0.77 | EGLN1 (0.55) | EGLN1EGLN2 | |
| SCHEMBL968156 | 0.77 | EGLN1 (0.48) | EGLN1 | |
| SCHEMBL967769 | 0.73 | EGLN1 (0.53) | EGLN1EGLN2THRATHRB | |
| SCHEMBL522183 | 0.72 | EGLN1 (0.64) | EGLN1THRATHRB | |
| SCHEMBL523787 | 0.72 | EGLN1 (0.58) | EGLN1THRATHRB | |
| SCHEMBL963733 | 0.71 | EGLN1 (0.53) | EGLN1EGLN2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919463-A2 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN, INC. (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-1866318-A2 | THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006138511-A2 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN, INC. (US) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006094292-A2 | THIENOPYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. (US) | 2006-09-08 | — | — | WO | disclosed |