Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | EDNRB | P24530 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138946 | 1.00 | EDNRA (0.39) | EDNRADDB1CRBNKEAP1NFE2L2 | |
| SCHEMBL5138948 | 1.00 | EDNRA (0.39) | EDNRADDB1CRBNKEAP1NFE2L2 | |
| SCHEMBL2895998 | 1.00 | EDNRA (0.39) | EDNRADDB1CRBNKEAP1NFE2L2 | |
| SCHEMBL2886920 | 1.00 | EDNRA (0.39) | EDNRADDB1CRBNKEAP1NFE2L2 | |
| SCHEMBL705280 | 0.80 | CYP1A2 (0.42) | CYP2C19CYP1A2ALDH1A1LMNAKMT2A | |
| SCHEMBL706577 | 0.80 | CYP1A2 (0.42) | CYP2C19CYP1A2ALDH1A1LMNAKMT2A | |
| SCHEMBL15194525 | 0.72 | DDB1 (0.39) | EDNRADDB1CRBNKEAP1NFE2L2 | |
| SCHEMBL2895444 | 0.72 | HDAC4 (0.43) | EDNRAEDNRBCYP2C19CYP1A2HDAC4 | |
| SCHEMBL2894414 | 0.72 | HDAC4 (0.43) | EDNRAEDNRBCYP2C19CYP1A2HDAC4 | |
| SCHEMBL5024864 | 0.72 | HDAC4 (0.43) | EDNRAEDNRBCYP2C19CYP1A2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898905-A2 | HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007002457-A2 | HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |