Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5107344 | 0.93 | BRAF (0.52) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5111641 | 0.88 | BRAF (0.55) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5118843 | 0.85 | HTR2A (0.45) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5139333 | 0.83 | KDR (0.49) | BRAFMAPK14RAF1KDR | |
| SCHEMBL5113288 | 0.83 | BRAF (0.57) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5110396 | 0.81 | BRAF (0.46) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5118777 | 0.80 | EPHX2 (0.50) | BRAFMAPK14RAF1KDREPHX2 | |
| SCHEMBL5114066 | 0.80 | BRAF (0.47) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5113819 | 0.80 | SRC (0.50) | BRAFMAPK14RAF1KDREGFR | |
| SCHEMBL5111764 | 0.79 | RAF1 (0.43) | BRAFRAF1KDREGFRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119466-A1 | Heteroarylphenylurea Derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1724258-A1 | HETEROARYLPHENYLUREA DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119466-A1 | Heteroarylphenylurea Derivative | CHRM1, CBR3, CHRM2 | BRAF 1735/4885MAPK14 1165/4885RAF1 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.