Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL5139770

Clc1cc(Cl)c(-c2ccccc2)cc1Cl.Clc1cc(Cl)c(-c2ccccc2)cc1Cl.S.S

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.56
CYP2A6 P11509 1/20 0.54
MAPK1 P28482 1/20 0.52
CSNK2A1 P68400 2/20 0.48
BACE1 P56817 1/20 0.44
PRKAB2 O43741 2/20 0.43
PRKAG1 P54619 2/20 0.43
PRKAA2 P54646 2/20 0.43
PRKAA1 Q13131 2/20 0.43
PRKAG3 Q9UGI9 2/20 0.43
PRKAG2 Q9UGJ0 2/20 0.43
PRKAB1 Q9Y478 2/20 0.43
ESR2 Q92731 1/20 0.40
CYP1A2 P05177 1/20 0.40
ESR1 P03372 1/20 0.40
ALDH1A1 P00352 3/20 0.39
HPGD P15428 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
NPC1 O15118 1/20 0.39
TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2934305 0.97 AHR (0.58) AHRCYP2A6MAPK1CSNK2A1BACE1
SCHEMBL29420036 0.97 AHR (0.58) AHRCYP2A6MAPK1CSNK2A1BACE1
SCHEMBL15653901 0.93 AHR (0.60) AHRCYP2A6MAPK1CSNK2A1BACE1
SCHEMBL8734809 0.79 CYP2A6 (0.48) AHRCYP2A6CSNK2A1BACE1PRKAB2
SCHEMBL10922908 0.79 CSNK2A1 (0.48) AHRCYP2A6MAPK1CSNK2A1BACE1
SCHEMBL11714090 0.79 BACE1 (0.56) AHRCYP2A6CSNK2A1BACE1PRKAB2
SCHEMBL20661350 0.78 CYP2A6 (0.52) CYP2A6MAPK1CSNK2A1BACE1PRKAB2
SCHEMBL4449938 0.77 AHR (0.65) AHRCYP2A6MAPK1CYP1A2TP53
SCHEMBL29801189 0.77 AHR (0.65) AHRCYP2A6MAPK1CYP1A2TP53
SCHEMBL24731021 0.76 MAPK1 (0.50) AHRCYP2A6MAPK1CSNK2A1BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1882713-B1 CURABLE COMPOSITION MITSUBISHI GAS CHEMICAL CO (JP) 2013-07-03 EP disclosed
EP-1882713-A1 CURABLE COMPOSITION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2008-01-30 EP disclosed