Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 7/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135738 | 0.86 | CASR (0.49) | CASRNR1I2PTGER1PTGER4PTGER3 | |
| SCHEMBL3345165 | 0.75 | CASR (0.56) | CASRNR1I2 | |
| SCHEMBL4139286 | 0.74 | CASR (0.66) | CASRNR1I2 | |
| SCHEMBL4138510 | 0.72 | CASR (0.67) | CASRNR1I2PTGER1PTGER4PTGER3 | |
| SCHEMBL4147810 | 0.72 | CASR (0.56) | CASRNR1I2BRD4 | |
| SCHEMBL4135676 | 0.72 | CASR (0.47) | CASRNR1I2PTGER1PTGER4PTGER3 | |
| SCHEMBL27751255 | 0.71 | CASR (0.51) | CASRNR1I2 | |
| SCHEMBL4144136 | 0.71 | CASR (0.51) | CASRNR1I2BRD4 | |
| SCHEMBL4142850 | 0.71 | NR1I2 (0.70) | CASRNR1I2PTGER1PTGER4PTGER3 | |
| SCHEMBL4138096 | 0.70 | CASR (0.69) | CASRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |