Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.38 |
| ▸ | CTSD | P07339 | 4/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582740 | 0.88 | BACE1 (0.57) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL3574077 | 0.70 | BACE1 (0.58) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL3580984 | 0.70 | BACE1 (0.51) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL3583507 | 0.69 | BACE1 (0.50) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL5139355 | 0.69 | BACE1 (0.51) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL3576718 | 0.67 | BACE1 (0.49) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL4109037 | 0.67 | BACE1 (0.76) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL3577724 | 0.67 | BACE1 (0.53) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL3580965 | 0.66 | BACE1 (0.53) | BACE1BACE2CTSDRENAPP | |
| SCHEMBL5135046 | 0.66 | BACE1 (0.60) | BACE1BACE2CTSDRENAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896454-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR -SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005366-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | disclosed |