Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.73 |
| ▸ | PLK3 | Q9H4B4 | 11/20 | 0.73 |
| ▸ | NEK2 | P51955 | 3/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | PIM1 | P11309 | 2/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.57 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.57 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.57 |
| ▸ | STK10 | O94804 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | GRK4 | P32298 | 1/20 | 0.57 |
| ▸ | TIE1 | P35590 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990389 | 1.00 | PLK1 (0.73) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2989078 | 0.93 | PLK1 (0.74) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL4406226 | 0.92 | PLK1 (0.84) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL4397857 | 0.91 | PLK1 (0.69) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2977844 | 0.90 | PLK1 (0.74) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL5578814 | 0.88 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2980126 | 0.88 | PLK1 (0.72) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL13206451 | 0.87 | PLK1 (0.71) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL13592859 | 0.87 | PLK1 (0.71) | PLK1PLK3NEK2PIK3CDPDGFRB | |
| SCHEMBL2977902 | 0.87 | PLK1 (0.73) | PLK1PLK3NEK2PIK3CDPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937671-A2 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SmithKline Beecham Corporation (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007030361-A2 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |