Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.35 |
| ▸ | CDK4 | P11802 | 4/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 5/20 | 0.33 |
| ▸ | CHUK | O15111 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411782 | 0.91 | RET (0.38) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL1411691 | 0.90 | SYK (0.38) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL3203746 | 0.89 | NEK2 (0.40) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL1411727 | 0.84 | IKBKB (0.46) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL3201287 | 0.84 | CDK2 (0.44) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL3201699 | 0.83 | CDK2 (0.41) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL3204027 | 0.80 | BRD4 (0.50) | CDK2CDK9CDK7CCNT1JAK2 | |
| SCHEMBL3192460 | 0.80 | CDK2 (0.46) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL3216553 | 0.79 | PTK2 (0.45) | CDK2CDK4CDK9CDK7CCNT1 | |
| SCHEMBL1412198 | 0.79 | CDK2 (0.50) | CDK2CDK4CDK9CDK7CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940846-A2 | PYRIMIDIN-4-YL-3,4-DIHYDRO-2H-PYRROLO[1,2A]PYRAZIN-1-ONE COMPOUNDS | Cyclacel Limited (GB) | 2008-07-09 | — | — | EP | claimed |
| WO-2007042784-A2 | PYRIMIDIN-4-YL-3, 4-DIHYDR0-2H- PYRROLO [1, 2A] PYRAZIN-1-ONE COMPOUNDS | CYCLACEL LIMITED (GB) | 2007-04-19 | — | — | WO | claimed |