Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 9/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5249932 | 1.00 | PLK1 (0.39) | PLK1PLK3CDK2IKBKEALDH1A1 | |
| SCHEMBL3156557 | 0.81 | PLK1 (0.35) | PLK1PLK3CDK2IKBKEALDH1A1 | |
| SCHEMBL2987855 | 0.79 | PLK1 (0.48) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL2504743 | 0.78 | KMT2A (0.44) | PLK1PLK3CDK2IKBKEALDH1A1 | |
| SCHEMBL2505199 | 0.74 | PLK1 (0.59) | PLK1 | |
| SCHEMBL2502714 | 0.74 | PLK1 (0.35) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL5265312 | 0.72 | PLK1 (0.47) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL5141390 | 0.72 | MCL1 (0.38) | ALDH1A1LMNAGAAGRM6HPGD | |
| SCHEMBL2500942 | 0.71 | PLK1 (0.36) | PLK1PLK3CDK2IKBKEGRM6 | |
| SCHEMBL2494455 | 0.71 | PLK1 (0.35) | PLK1PLK3CDK2IKBKECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937671-A2 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SmithKline Beecham Corporation (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007030361-A2 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |