Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.60 |
| ▸ | CDC25B | P30305 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CDC25A | P30304 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.52 |
| ▸ | NSD2 | O96028 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CDC25C | P30307 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-Phenylamino Benzoic Acid SCHEMBL4345076 | 0.87 | RHOA (0.77) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL5142332 | 0.80 | TP53 (0.50) | AKR1C3AKR1C2CDC25BRAB9AMAPT | |
| SCHEMBL13280136 | 0.79 | AKR1C3 (0.65) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL2424568 | 0.79 | AKR1C3 (0.69) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL13280274 | 0.79 | AKR1C3 (0.65) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL13280280 | 0.79 | AKR1C3 (0.65) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL10567724 | 0.79 | RHOA (0.66) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL13465068 | 0.79 | MEN1 (0.61) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL5460527 | 0.78 | AKR1C3 (0.67) | RHOAAKR1C3AKR1C2CDC25BRAB9A | |
| SCHEMBL9937965 | 0.77 | AKR1C3 (0.55) | RHOAAKR1C3AKR1C2CDC25BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423111-A4 | FXR NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2007-04-18 | — | — | EP | disclosed |
| US-7034046-B2 | NR1H4 nuclear receptor binding compounds | PHENEX PHARMACEUTICALS AG (DE) | 2006-04-25 | — | — | US | disclosed |
| EP-1423111-A1 | FXR NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS | LION Bioscience AG (DE) | 2004-06-02 | — | — | EP | disclosed |
| US-20030187042-A1 | NR1H4 nuclear receptor binding compounds | PHENEX PHARMACEUTICALS AG (DE) | 2003-10-02 | — | — | US | disclosed |
| WO-2003015771-A1 | FXR NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS | LION BIOSCIENCE AG (DE) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187042-A1 | NR1H4 nuclear receptor binding compounds | NR1H4, NR1H2, NR1H3 | RHOA 4245/4885AKR1C3 566/4885AKR1C2 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.