Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142642 | 1.00 | ADORA2A (0.72) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7307851 | 0.91 | ADORA2A (0.72) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7307860 | 0.91 | ADORA2A (0.72) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7732154 | 0.89 | ADORA2A (0.75) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7732157 | 0.89 | ADORA2A (0.75) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7548317 | 0.87 | ADORA2A (0.61) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7548324 | 0.87 | ADORA2A (0.61) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7343340 | 0.87 | ADORA2A (0.79) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7343327 | 0.87 | ADORA2A (0.79) | ADORA2AADORA3ADORA2B | |
| SCHEMBL7543255 | 0.86 | ADORA2A (0.68) | ADORA2AADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037833-A1 | Compositions and methods for inhibiting neurodegeneration | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 2007-02-15 | — | — | US | claimed |
| US-5859019-A | Methods for protecting against cardiac ischemia by administering adenosine A2a receptor antagonists | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-01-12 | — | — | US | claimed |
| EP-0628311-B1 | Xanthine-Derivatives as Antidepressants | KYOWA HAKKO KOGYO KK (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-5861405-A | A2-SELECTIVE ADENOSINE RECEPTOR ANTAGONIST AS ANTIDEPRESSANTS AND CNS STIMULANTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-01-19 | — | — | US | disclosed |
| EP-0565377-B1 | Therapeutic agents for use in the treatment of Parkinson's Disease | KYOWA HAKKO KOGYO KK (JP) | 1998-01-07 | — | — | EP | disclosed |
| US-5587378-A | ADMINISTERING A SUBSTITUTED XANTHINE COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| US-5543415-A | ADMINISTERING A XANTHINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| US-5484920-A | XANTHINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-01-16 | — | — | US | disclosed |
| EP-0628311-A1 | ANTIDEPRESSANT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-12-14 | — | — | EP | disclosed |
| WO-1994025462-A1 | 8-SUBSTITUTED 1,3,7-TRIALKYL-XANTHINE DERIVATIVES AS A2-SELECTIVE ADENOSINE RECEPTOR ANTAGONISTS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE (US) | 1994-11-10 | — | — | WO | disclosed |
| EP-0565377-A1 | Therapeutic agents for use in the treatment of parkinson's disease | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-10-13 | — | — | EP | disclosed |