Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.41 |
| ▸ | EGFR | P00533 | 7/20 | 0.40 |
| ▸ | IGF1R | P08069 | 4/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | CSK | P41240 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | PRKDC | P78527 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | HCK | P08631 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400087 | 0.88 | KDR (0.43) | SRCEGFRIGF1RERBB2ERBB3 | |
| SCHEMBL399508 | 0.87 | KDR (0.46) | SRCEGFRIGF1RERBB2ERBB3 | |
| SCHEMBL401211 | 0.84 | KDR (0.51) | SRCEGFRKDRPIK3CDPIK3CA | |
| Carbamic Acid SCHEMBL19244765 | 0.83 | PIK3CD (0.49) | SRCEGFRKDRPIK3CDPIK3CA | |
| SCHEMBL397895 | 0.83 | PIK3CD (0.43) | SRCEGFRIGF1RERBB2ERBB3 | |
| SCHEMBL19244753 | 0.82 | RET (0.48) | SRCEGFRKDRPIK3CDPIK3CA | |
| SCHEMBL397959 | 0.81 | PIK3CD (0.42) | SRCEGFRIGF1RERBB2ERBB3 | |
| SCHEMBL402172 | 0.80 | PIK3CD (0.38) | SRCEGFRIGF1RERBB2ERBB3 | |
| SCHEMBL5137831 | 0.79 | PIK3CD (0.41) | SRCEGFRKDRPIK3CDPIK3CA | |
| SCHEMBL402364 | 0.77 | IGF1R (0.40) | SRCEGFRIGF1RERBB2ERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | claimed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |