Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6054221 | 0.88 | MAP2K1 (0.71) | MAP2K1 | |
| SCHEMBL13046489 | 0.80 | MAP2K1 (0.55) | MAP2K1 | |
| SCHEMBL3685754 | 0.79 | MAP2K1 (1.00) | MAP2K1 | |
| SCHEMBL6054237 | 0.79 | MAP2K1 (0.59) | MAP2K1RAF1 | |
| SCHEMBL6054341 | 0.77 | MAP2K1 (0.79) | MAP2K1 | |
| SCHEMBL3691739 | 0.77 | MAP2K1 (0.81) | MAP2K1 | |
| SCHEMBL5138265 | 0.76 | MAP2K1 (0.87) | MAP2K1 | |
| SCHEMBL3687441 | 0.76 | MAP2K1 (0.89) | MAP2K1 | |
| SCHEMBL13046828 | 0.76 | MAP2K1 (0.87) | MAP2K1 | |
| SCHEMBL3691482 | 0.75 | MAP2K1 (0.86) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030112-B2 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-18 | — | — | US | claimed |
| EP-1664051-A4 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BRISTOL MYERS SQUIBB CO (US) | 2008-12-31 | — | — | EP | disclosed |
| EP-1664051-A2 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Bristol-Myers Squibb Company (US) | 2006-06-07 | — | — | EP | disclosed |
| US-7030112-B2 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-04-18 | — | — | US | disclosed |
| WO-2005030144-A2 | PYRROLOPYRIDAZINE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-07 | — | — | WO | disclosed |