Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983073 | 0.74 | MAPK13 (0.42) | ABL1BCRNPC1ALDH1A1MAPT | |
| SCHEMBL2987501 | 0.73 | ABL1 (0.34) | ABL1BCR | |
| SCHEMBL2984731 | 0.69 | PDE7A (0.34) | ABL1BCRHDAC6KDM4ENPC1 | |
| SCHEMBL653889 | 0.68 | APP (0.42) | ALDH1A1MAPT | |
| SCHEMBL25128096 | 0.67 | ABL1 (0.40) | ABL1BCRMETHTR2CNPC1 | |
| SCHEMBL27708241 | 0.67 | ADORA2A (0.40) | KDM4ENPC1ALDH1A1LMNAMAPT | |
| SCHEMBL2984648 | 0.67 | CYP2A6 (0.42) | PTGS2KDM4EALDH1A1MAPT | |
| SCHEMBL2965386 | 0.66 | ADORA2A (0.50) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL27708240 | 0.63 | BTK (0.30) | — | |
| SCHEMBL2980750 | 0.63 | HDAC6 (0.43) | ABL1BCRHDAC6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |