Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.41 |
| ▸ | SRC | P12931 | 11/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.41 |
| ▸ | HCK | P08631 | 9/20 | 0.41 |
| ▸ | KDR | P35968 | 9/20 | 0.41 |
| ▸ | EGFR | P00533 | 8/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.41 |
| ▸ | MTOR | P42345 | 8/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.41 |
| ▸ | PRKDC | P78527 | 8/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.41 |
| ▸ | RET | P07949 | 8/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868687 | 0.80 | ABL1 (0.58) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16375259 | 0.67 | SRC (0.44) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4572199 | 0.66 | SRC (0.54) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4572200 | 0.66 | SRC (0.54) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL10261918 | 0.66 | SRC (0.66) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15956509 | 0.64 | SRC (0.47) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4572203 | 0.64 | SRC (0.44) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4572206 | 0.64 | SRC (0.47) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL6925165 | 0.63 | SRC (0.58) | ABL1SRCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5015920 | 0.63 | RET (0.48) | SRCKDREGFRRETRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004654-A2 | KINASE ANTAGONISTS | The Regents of the University of California (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007114926-A2 | KINASE ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-11 | — | — | WO | disclosed |