Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Finasteride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 known ✓ | P31213 | 9/20 | 1.00 |
| ▸ | SRD5A1 | P18405 | 16/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | HSD3B1 | P14060 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Finasteride SCHEMBL1560981 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL11909 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL5509 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL13575812 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL21969512 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL3982016 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL22032590 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL22564355 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL21969513 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 | |
| Finasteride SCHEMBL6448111 | 1.00 | SRD5A1 (1.00) | SRD5A1SRD5A2LMNACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675838-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | Puretecch LYT, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10568900-B1 | Androgen effectors | PAXTON PIERSON SUZANNE JANINE (US) | 2020-02-25 | — | — | US | disclosed |
| CN-110448525-A | A kind of external application Finasteride lipid nanometer preparation and preparation method thereof prevented hair loss with growth-promoting hair | WUXI PAILIEBO BIOLOGICAL MEDICINE TECH CO LTD | 2019-11-15 | — | — | CN | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| US-10111895-B2 | Androgen effectors | Paxton-Pierson, Suzanne J. (US) | 2018-10-30 | — | — | US | disclosed |
| US-20170151271-A1 | Novel Androgen Effectors | PAXTON-PIERSON SUZANNE JANINE (US) | 2017-06-01 | — | — | US | disclosed |
| EP-3171859-A1 | PHARMACEUTICAL COMPOSITION COMPRISING 5ALPHA-REDUCTASE INHIBITOR | Chong Kun Dang Pharmaceutical Corp. (KR) | 2017-05-31 | — | — | EP | disclosed |
| US-20160175436-A1 | COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGY THERAPIES | VICUS THERAPEUTICS LLC (US) | 2016-06-23 | — | — | US | disclosed |
| WO-2016013829-A1 | PHARMACEUTICAL COMPOSITION COMPRISING 5ALPHA-REDUCTASE INHIBITOR | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2016-01-28 | — | — | WO | disclosed |
| EP-1868432-A2 | METHODS FOR TREATING ANXIETY RELATED DISORDERS | Hythiam, Inc. (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006110580-A2 | METHODS FOR TREATING ANXIETY RELATED DISORDERS | HYTHIAM, INC. (US) | 2006-10-19 | — | — | WO | disclosed |
| US-6048869-A | REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | disclosed |
| US-5574011-A | LH-RH DERIVATIVES | TIEN, PAUL S. | 1996-11-12 | — | — | US | disclosed |
| US-5344651-A | Steroid antisecretory agents for sebaceous glands of scalp, hair growth regulators, antiinflammatory agents and treatment of acne | THE PROCTER & GAMBLE COMPANY (US) | 1994-09-06 | — | — | US | disclosed |