Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700323 | 0.92 | PIK3CB (0.48) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2954006 | 0.81 | PIK3CB (0.49) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL3696106 | 0.79 | PIK3CB (0.65) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL2954762 | 0.74 | PIK3CB (0.60) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL2956597 | 0.74 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2955577 | 0.73 | PIK3CB (0.53) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL2954585 | 0.73 | PIK3CB (0.53) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL2947721 | 0.72 | PIK3CB (0.52) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL373245 | 0.72 | PDCD1 (0.56) | PDCD1CD274ATRCHEK1ATRIP | |
| SCHEMBL2948267 | 0.72 | PIK3CB (0.52) | PDCD1CD274ATRCHEK1ATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1864665-A1 | IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2007-12-12 | — | — | EP | claimed |
| EP-1864665-A1 | IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2007-12-12 | — | — | EP | disclosed |