Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151920 | 0.95 | MEN1 (0.74) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| Dinsed SCHEMBL1814194 | 0.88 | KMT2A (1.00) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL5152165 | 0.86 | KMT2A (0.78) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL2034554 | 0.86 | KMT2A (0.78) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL4031052 | 0.85 | KMT2A (0.76) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL4070269 | 0.85 | KMT2A (0.76) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL27625297 | 0.83 | KMT2A (0.83) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL3025870 | 0.83 | KMT2A (0.83) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL3973449 | 0.83 | MEN1 (0.72) | KMT2AMEN1CYP19A1ALDH1A1POLB | |
| SCHEMBL6447029 | 0.82 | MEN1 (0.67) | KMT2AMEN1CYP19A1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312225-B2 | Macrocyclic pyrimidines, their production and use as pharmaceutical agents | BAYER SCHERING PHARMA AG (DE) | 2007-12-25 | — | — | US | disclosed |
| US-20040209895-A1 | inhibit cyclin-dependent kinases and VEGF-receptor tyrosine kinases | SCHERING AG (DE) | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209895-A1 | inhibit cyclin-dependent kinases and VEGF-receptor tyrosine kinases | CCNK, CDK2, CDK1 | KMT2A 3155/4885MEN1 2527/4885CYP19A1 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.