Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 20/20 | 0.69 |
| ▸ | CDK2 | P24941 | 20/20 | 0.69 |
| ▸ | KDR | P35968 | 18/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.66 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.66 |
| ▸ | CDK4 | P11802 | 5/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367848 | 1.00 | CDK1 (0.69) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14112842 | 0.85 | CDK1 (0.78) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14140889 | 0.83 | CDK1 (0.75) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL4580255 | 0.82 | CDK1 (0.74) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL4584811 | 0.82 | CDK1 (0.74) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14163448 | 0.82 | CDK1 (0.74) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14163342 | 0.82 | CDK1 (0.74) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL3931191 | 0.82 | CDK1 (1.00) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL14367844 | 0.81 | CDK1 (0.69) | CDK1CDK2KDRCCNB1CCNE1 | |
| SCHEMBL5180209 | 0.81 | CDK1 (0.63) | CDK1CDK2KDRCCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288547-B2 | CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents | SCHERING AG (DE) | 2007-10-30 | — | — | US | disclosed |
| EP-1483260-A1 | CDK INHIBITING 2-HETEROARYL PYRIMIDINE, THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | Schering Aktiengesellschaft (DE) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003076437-A1 | CDK INHIBITING 2-HETEROARYL PYRIMIDINE, THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-09-18 | — | — | WO | disclosed |