Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399513 | 0.92 | HDAC8 (0.50) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL4402216 | 0.92 | HDAC8 (0.50) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL4403568 | 0.92 | HDAC8 (0.50) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL4409524 | 0.87 | HDAC8 (0.45) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL4399550 | 0.87 | HDAC8 (0.45) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL4404852 | 0.87 | HDAC8 (0.45) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL4399546 | 0.87 | HDAC8 (0.45) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL31203407 | 0.85 | NPC1 (0.63) | NPC1RAB9AMAPTGAAHDAC8 | |
| SCHEMBL31203536 | 0.82 | MAPT (0.66) | NPC1RAB9AMAPTMAPK1HDAC8 | |
| SCHEMBL31203375 | 0.81 | PTPN1 (0.53) | NPC1RAB9AMAPTHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745044-A2 | BENZOTHIAZOLE DERIVATIVES HAVING CDK MODULATING ACTIVITY AND USE THEREOF AS ANTICANCER AGENTS | Aventis Pharma S.A. (FR) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005097787-A2 | NOVEL BENZOTHIAZOLES AND THE USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA S.A. (FR) | 2005-10-20 | — | — | WO | disclosed |