Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.36 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854290 | 0.90 | CYP2C19 (0.51) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL3860285 | 0.90 | CA12 (0.43) | CA12CA2CA9ALDH1A1SMN1; SMN2 | |
| SCHEMBL5156755 | 0.89 | MEN1 (0.39) | CA12CA2CA9ALDH1A1KDM4E | |
| SCHEMBL3343555 | 0.86 | CYP2C9 (0.55) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL3854890 | 0.84 | CA12 (0.51) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL3854418 | 0.84 | CA12 (0.51) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL5174852 | 0.82 | CA12 (0.39) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL5154034 | 0.82 | CYP2C19 (0.44) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL5156302 | 0.82 | CYP2C9 (0.44) | CYP2C9CYP2C19CA12CA2CA9 | |
| SCHEMBL5153384 | 0.81 | CYP2C9 (0.43) | CYP2C9CYP2C19CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |