⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1467658 | 0.88 | TDP1 (0.31) | — | |
| SCHEMBL4818147 | 0.86 | TDP1 (0.33) | — | |
| SCHEMBL6676603 | 0.84 | TDP1 (0.36) | — | |
| SCHEMBL29000774 | 0.84 | TDP1 (0.36) | — | |
| SCHEMBL7672790 | 0.83 | TSHR (0.36) | — | |
| SCHEMBL3327598 | 0.82 | TDP1 (0.31) | — | |
| SCHEMBL4203974 | 0.80 | — | — | |
| SCHEMBL9563418 | 0.78 | — | — | |
| SCHEMBL21293786 | 0.78 | — | — | |
| SCHEMBL567668 | 0.78 | TDP1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329338-B1 | CYCLIC OLIGOPEPTIDE TETRAESTES | MEIJI SEIKA KAISHA, LTD. (JP) | 2001-12-11 | — | — | US | claimed |
| EP-0903347-A1 | NOVEL CYCLIC DEPSIPEPTIDE PF1022 DERIVATIVES | MEIJI SEIKA KAISHA LTD. (JP) | 1999-03-24 | — | — | EP | claimed |
| CN-103073726-B | Segmented copolymer and liquid composition and nucleic acid preparation and its preparation method and application | SHENZHEN RIBO BIOTECHNOLOGY CO., LTD. (CN) | 2015-09-23 | — | — | CN | disclosed |
| US-20070054909-A1 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | US | disclosed |
| US-7179819-B2 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-02-20 | — | — | US | disclosed |
| US-6831175-B2 | Such as N,N-dimethyl-N-(2-((5-((E)-2-pyridin-4-ylvinyl) pyridin-3-yl)oxy)ethyl)amine | ABBOTT LABORATORIES | 2004-12-14 | — | — | US | disclosed |
| US-20040229858-A1 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-11-18 | — | — | US | disclosed |
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| US-6756378-B2 | BENZYL -UREA, -THIOUREA, OR -GUANIDINE DERIVATIVES THAT INHIBIT THE BINDING OF LIGANDS TO ALPHA 4 BETA 1 INTEGRIN (VLA-4) | PHARMACOPEIA DRUG DISCOVERY, INC. | 2004-06-29 | — | — | US | disclosed |
| US-6696500-B2 | BIOACTIVE SUBSTANCE HAVING ACIDIC GROUP AND A BIODEGRADABLE POLYMER HAVING AN OPTIONALLY PROTECTED BASIC GROUP, SUCH AS A POLYLACTONE THAT HAS BEEN ESTERIFIED, AMIDATED, OR THIOESTERIFIED WITH A COMPOUND HAVING CYCLIC AMINO GROUPS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-02-24 | — | — | US | disclosed |
| EP-0815853-B1 | Sustained-release preparation for bioactive substance having an acidic group | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-01-21 | — | — | EP | disclosed |
| EP-0779281-A1 | ISOXAZOLES | SANKYO COMPANY LIMITED (JP) | 1997-06-18 | — | — | EP | disclosed |
| US-5599587-A | Phosphoric acid esters and their use in the preparation of biocompatible surfaces | BIOCOMPATIBLES LIMITED (GB) | 1997-02-04 | — | — | US | disclosed |
| EP-0426804-B1 | 2-(2-HYDROXY-3-PHENOXYPROPYLAMINO)-ETHOXYBENZENE DERIVATIVES | ICI PLC (GB) | 1994-01-19 | — | — | EP | disclosed |
| EP-0427480-B1 | 2-Hydroxy-3-phenoxypropylamino compounds | ICI PLC (GB) | 1994-01-12 | — | — | EP | disclosed |
| EP-0565317-A1 | (2-(2-hydroxy-2 phenylethylamino)ethoxy) phenyl derivatives, processes and intermediates for their preparation, pharmaceutical compositions containing them and their use as Beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1993-10-13 | — | — | EP | disclosed |
| US-5187190-A | PHENOXYPROPANOLAMINE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-16 | — | — | US | disclosed |
| EP-0427480-A1 | 2-Hydroxy-3-phenoxypropylamino compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-05-15 | — | — | EP | disclosed |
| EP-0426804-A1 | 2-(2-HYDROXY-3-PHENOXYPROPYLAMINO)-ETHOXYBENZENE DERIVATIVES. | ICI PLC (GB) | 1991-05-15 | — | — | EP | disclosed |
| WO-1990013535-A1 | COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-11-15 | — | — | WO | disclosed |