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SCHEMBL5157256

SCHEMBL5157256

Cc1ccc(NC(=O)c2ccc(C(N)=O)cc2)cc1Nc1ncc(-c2cccnc2)o1.Cc1oncc1C(=O)O.O=C(Nc1ccc(Cl)c(Nc2ncc(-c3cccnc3)o2)c1)c1cccc(C(F)(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 7/20 0.48
▸ CSF1R P07333 5/20 0.48
▸ PIKFYVE Q9Y2I7 3/20 0.48
▸ TEK Q02763 2/20 0.45
▸ KIT P10721 2/20 0.45
▸ EPHB2 P29323 1/20 0.44
▸ DDR1 Q08345 1/20 0.44
▸ DDR2 Q16832 1/20 0.44
▸ ABL1 P00519 2/20 0.43
▸ BCR P11274 1/20 0.43
▸ KDR P35968 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL543756 0.84 CSF1R (0.59) BRAFCSF1RPIKFYVETEKKIT
SCHEMBL544211 0.80 ABL1 (0.58) KITABL1BCRKDR
SCHEMBL544729 0.78 BRAF (0.60) BRAFCSF1RPIKFYVETEKKIT
SCHEMBL544249 0.76 BRAF (0.56) BRAFCSF1RPIKFYVETEKKIT
SCHEMBL544076 0.75 ABL1 (0.62) BRAFCSF1RPIKFYVEABL1BCR
SCHEMBL544438 0.74 BRAF (0.53) BRAFCSF1RPIKFYVEKITABL1
SCHEMBL543608 0.74 TSHR (0.60) BRAFCSF1RPIKFYVEKITABL1
SCHEMBL544504 0.74 ABL1 (0.58) KITABL1BCRKDR
SCHEMBL544589 0.73 ABL1 (0.55) BRAFKITDDR2ABL1BCR
SCHEMBL543745 0.73 POLB (0.55) BRAFCSF1RPIKFYVEKITABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1742633-A2 USE OF C-KIT INHIBITORS FOR TREATING FIBROSIS AB Science (FR) 2007-01-17 — — EP disclosed
WO-2005115304-A2 USE OF C-KIT INHIBITORS FOR TREATING FIBRODYSPLASIA AB SCIENCE (FR) 2005-12-08 — — WO disclosed
WO-2005115385-A1 USE OF C-KIT INHIBITORS FOR TREATING ACNE AB SCIENCE (FR) 2005-12-08 — — WO disclosed
WO-2005102346-A2 USE OF C-KIT INHIBITORS FOR TREATING FIBROSIS AB SCIENCE (FR) 2005-11-03 — — WO disclosed