Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159454 | 0.91 | CYP2C9 (0.43) | CYP2C9CAPN1TNKSTNKS2PARP1 | |
| SCHEMBL5160619 | 0.87 | TNKS (0.41) | CYP2C9CAPN1TNKSTNKS2PGR | |
| SCHEMBL7485354 | 0.87 | CYP2C9 (0.48) | CYP2C9CAPN1TNKSTNKS2PARP1 | |
| SCHEMBL5160100 | 0.85 | CAPN1 (0.41) | CYP2C9CAPN1TNKSTNKS2PARP1 | |
| SCHEMBL5157936 | 0.83 | CYP2C9 (0.40) | CYP2C9CAPN1TNKSTNKS2PGR | |
| SCHEMBL5162844 | 0.82 | CYP2C9 (0.58) | CYP2C9CAPN1PARP1PGRKDM4E | |
| SCHEMBL5157642 | 0.81 | CYP2C9 (0.65) | CYP2C9ALDH1A1MAP2 | |
| SCHEMBL5163422 | 0.79 | CYP2C9 (0.68) | CYP2C9CAPN1PARP1PGRKDM4E | |
| SCHEMBL5157420 | 0.78 | CYP2C9 (0.49) | CYP2C9CAPN1PGRKDM4EALDH1A1 | |
| SCHEMBL5160533 | 0.78 | CYP2C9 (0.61) | CYP2C9CAPN1PARP1PGRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133474-B1 | 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2007-02-21 | — | — | EP | claimed |