Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 19/20 | 0.54 |
| ▸ | ICAM1 | P05362 | 19/20 | 0.54 |
| ▸ | ITGAL | P20701 | 19/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4888210 | 0.89 | ITGB2 (0.54) | ITGB2ICAM1ITGAL | |
| SCHEMBL14066359 | 0.89 | ITGB2 (0.54) | ITGB2ICAM1ITGAL | |
| SCHEMBL14066352 | 0.79 | ITGB2 (0.59) | ITGB2ICAM1ITGAL | |
| SCHEMBL4895580 | 0.79 | ITGB2 (0.59) | ITGB2ICAM1ITGAL | |
| SCHEMBL7646849 | 0.78 | ITGB2 (0.74) | ITGB2ICAM1ITGAL | |
| SCHEMBL7065998 | 0.72 | ITGB2 (0.51) | ITGB2ICAM1ITGALKDM4EHPGD | |
| SCHEMBL5447039 | 0.72 | ITGB2 (0.81) | ITGB2ICAM1ITGAL | |
| SCHEMBL14362396 | 0.72 | ITGB2 (0.81) | ITGB2ICAM1ITGAL | |
| SCHEMBL5452976 | 0.72 | ITGB2 (0.81) | ITGB2ICAM1ITGAL | |
| SCHEMBL4895830 | 0.71 | ITGB2 (0.71) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740561-A2 | ARYLPHENYLAMINO-AND ARYLPHENYLETHER-SULFIDE DERIVATIVES, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ICOS Corporation (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105766-A2 | ARYLPHENYLAMINO-AND ARYLPHENYLETHER-SULFIDE DERIVATIVES, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ICOS CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |