Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | HCN1 | O60741 | 1/20 | 0.53 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976400 | 1.00 | KCNA3 (0.76) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL5157294 | 0.88 | KCNA3 (0.75) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL14976803 | 0.88 | KCNA3 (0.60) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL10330502 | 0.85 | KCNA3 (0.70) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL4965050 | 0.84 | KCNA3 (0.69) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL5159523 | 0.83 | KCNA3 (0.68) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL5159459 | 0.83 | KCNA3 (0.68) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL5162069 | 0.81 | KCNA3 (0.65) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL7976348 | 0.81 | KCNA3 (0.65) | KCNA3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL6207609 | 0.81 | NPC1 (0.71) | KCNA3NPC1RAB9AHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126836-B1 | BENZAMIDE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2007-02-14 | — | — | EP | disclosed |
| US-6194458-B1 | 1-(2-METHOXYPHENYL)-1-OXO-2-AZA-(S)-4-I-BUTYL-4-PHENYLBUTANE, FOR EXAMPLE; TREATING VARIOUS CONDITIONS INCLUDING TRANSPLANTATION REJECTION OF ORGANS OR TISSUES IN A PATIENT; IMMUNOSUPPRESSANT COMPOSITIONS | MERCK & CO., INC. | 2001-02-27 | — | — | US | disclosed |