Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | PIKFYVE | Q9Y2I7 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | TEK | Q02763 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544076 | 0.88 | ABL1 (0.62) | BRAFCSF1RABL1BCRPIKFYVE | |
| SCHEMBL543652 | 0.85 | BRAF (0.58) | BRAFCSF1RABL1BCRMAPK14 | |
| SCHEMBL543745 | 0.83 | POLB (0.55) | BRAFCSF1RABL1BCRPIKFYVE | |
| SCHEMBL544729 | 0.78 | BRAF (0.60) | BRAFCSF1RABL1PIKFYVEMAPK14 | |
| SCHEMBL544249 | 0.78 | BRAF (0.56) | BRAFCSF1RABL1BCRPIKFYVE | |
| SCHEMBL543756 | 0.77 | CSF1R (0.59) | BRAFCSF1RABL1BCRPIKFYVE | |
| SCHEMBL543608 | 0.75 | TSHR (0.60) | BRAFCSF1RABL1BCRPIKFYVE | |
| SCHEMBL543733 | 0.74 | BRAF (0.66) | BRAFCSF1RPIKFYVEKDRTEK | |
| SCHEMBL544438 | 0.74 | BRAF (0.53) | BRAFCSF1RABL1BCRPIKFYVE | |
| SCHEMBL544504 | 0.73 | ABL1 (0.58) | ABL1BCRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742633-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBROSIS | AB Science (FR) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005115304-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBRODYSPLASIA | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005115385-A1 | USE OF C-KIT INHIBITORS FOR TREATING ACNE | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005102346-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBROSIS | AB SCIENCE (FR) | 2005-11-03 | — | — | WO | disclosed |