Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 13/20 | 0.71 |
| ▸ | CNR2 | P34972 | 11/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163296 | 0.86 | CNR1 (0.54) | CNR1CNR2SMN1; SMN2CYP2C9NPC1 | |
| SCHEMBL5236479 | 0.85 | CNR1 (0.73) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5164108 | 0.83 | CNR1 (1.00) | CNR1CNR2CYP2C9ALDH1A1NPC1 | |
| SCHEMBL5236769 | 0.80 | CNR1 (0.66) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5230358 | 0.78 | CNR1 (0.72) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5232573 | 0.78 | CNR1 (0.70) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5238904 | 0.77 | CNR1 (0.72) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5238111 | 0.77 | CNR1 (0.69) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5236233 | 0.75 | CNR1 (0.67) | CNR1CNR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5235653 | 0.75 | CNR1 (0.71) | CNR1CNR2KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756061-A1 | THERAPEUTIC COMPOUNDS: PYRIDINE N OXIDE SCAFFOLD | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115987-A1 | THERAPEUTIC COMPOUNDS: PYRIDINE N OXIDE SCAFFOLD | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756061-A1 | THERAPEUTIC COMPOUNDS: PYRIDINE N OXIDE SCAFFOLD | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115987-A1 | THERAPEUTIC COMPOUNDS: PYRIDINE N OXIDE SCAFFOLD | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |