SCHEMBL5160237

SCHEMBL5160237

Cc1cc2nc3ccc(C(F)(F)F)cc3nc2cc1C

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.59
NQO2 P16083 2/20 0.54
BACE1 P56817 1/20 0.46
NPBWR1 P48145 2/20 0.44
EPHX2 P34913 1/20 0.43
SCN4A P35499 1/20 0.43
DHFR P00374 3/20 0.42
CCNE2 O96020 1/20 0.41
CCNA2 P20248 1/20 0.41
CCNE1 P24864 1/20 0.41
CDK2 P24941 1/20 0.41
CCNA1 P78396 1/20 0.41
DHODH Q02127 1/20 0.40
PKM P14618 1/20 0.40
PDE10A Q9Y233 2/20 0.39
PDE2A O00408 1/20 0.39
PDE7A Q13946 1/20 0.39
DYRK1A Q13627 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13641613 0.83 KDM4E (0.63) KDM4ENQO2BACE1NPBWR1EPHX2
SCHEMBL12355859 0.81 KDM4E (0.66) KDM4EBACE1NPBWR1EPHX2SCN4A
SCHEMBL12355858 0.81 KDM4E (0.66) KDM4EBACE1NPBWR1EPHX2SCN4A
SCHEMBL18538194 0.79 KDM4E (0.54) KDM4ENQO2BACE1NPBWR1EPHX2
SCHEMBL18538190 0.79 KDM4E (0.54) KDM4ENQO2BACE1NPBWR1EPHX2
SCHEMBL11809163 0.79 KDM4E (0.63) KDM4EBACE1NPBWR1EPHX2SCN4A
SCHEMBL12502947 0.78 KDM4E (0.53) KDM4EBACE1NPBWR1DHFRPDE10A
SCHEMBL12502830 0.78 KDM4E (0.53) KDM4EBACE1NPBWR1DHFRPDE10A
SCHEMBL437476 0.78 KDM4E (0.61) KDM4EBACE1NPBWR1EPHX2SCN4A
SCHEMBL6107899 0.78 KDM4E (0.72) KDM4EBACE1NPBWR1EPHX2SCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1457813-B1 An improved electrochromic medium capable of producing a pre-selected color GENTEX CORP (US) 2007-01-24 EP disclosed
EP-1457813-A2 An improved electrochromic medium capable of producing a pre-selected color Gentex Corporation (US) 2004-09-15 EP disclosed
EP-0972227-B1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORP (US) 2004-07-14 EP disclosed
US-6037471-A FOR ELECTROCHROMIC MIRRORS FOR MOTOR VEHICLES GENTEX CORPORATION (US) 2000-03-14 US disclosed
US-6020987-A Electrochromic medium capable of producing a pre-selected color GENTEX CORPORATION (US) 2000-02-01 US disclosed
EP-0972227-A1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORPORATION (US) 2000-01-19 EP disclosed
US-5998617-A MIXTURE OF ELECTROACTIVE MATERIALS AT PRESELECTIVE CONCENTRATION; GRAY COLOR GENTEX CORPORATION (US) 1999-12-07 US disclosed
WO-1998044384-A1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORPORATION (US) 1998-10-08 WO disclosed