Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 13/20 | 0.66 |
| ▸ | LIPE | Q05469 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160039 | 0.88 | CNR1 (0.66) | CNR1LIPECNR2 | |
| SCHEMBL5160389 | 0.88 | CNR1 (0.66) | CNR1LIPEKDM1A | |
| SCHEMBL5159475 | 0.88 | CNR1 (0.65) | CNR1LIPECNR2 | |
| SCHEMBL5158234 | 0.86 | CNR1 (0.69) | CNR1LIPE | |
| SCHEMBL4461228 | 0.80 | CNR1 (1.00) | CNR1CNR2 | |
| SCHEMBL5159918 | 0.79 | CNR1 (0.66) | CNR1KDM1AEP300 | |
| SCHEMBL5159993 | 0.79 | CNR1 (0.71) | CNR1LIPECNR2 | |
| SCHEMBL5160432 | 0.79 | CNR1 (0.71) | CNR1LIPECNR2 | |
| SCHEMBL5159697 | 0.75 | CNR1 (0.67) | CNR1LIPE | |
| SCHEMBL18222380 | 0.69 | CNR2 (0.72) | CNR1LIPECNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458690-B1 | 5,6-DIARYL-PYRAZINE-2-AMIDE DERIVATIVES AS CB1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | claimed |