SCHEMBL5161332

SCHEMBL5161332

COc1ccc(Cl)cc1-c1c(CC(=O)O)c(=O)[nH]c2ccc(C(F)(F)F)cc12

nearest known ligand 0.78

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 7/20 0.78
CYP3A4 P08684 2/20 0.57
CYP1A2 P05177 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C19 P33261 1/20 0.57
PIM1 P11309 1/20 0.44
PTGDR2 Q9Y5Y4 5/20 0.44
TBXA2R P21731 2/20 0.43
PTGDR Q13258 2/20 0.43
PTGIR P43119 1/20 0.43
MAP2 P11137 1/20 0.42
CTSA P10619 1/20 0.40
SLC26A3 P40879 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5157966 0.91 CYP2C9 (0.81) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5161705 0.90 CYP2C9 (0.87) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5161367 0.87 CYP2C9 (1.00) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5159637 0.86 CYP2C9 (0.76) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5159376 0.86 CYP2C9 (0.89) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5159266 0.85 CYP2C9 (0.69) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL14580606 0.85 CYP2C9 (0.67) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL7487055 0.84 CYP2C9 (0.73) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5157415 0.84 CYP2C9 (0.73) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19
SCHEMBL5157433 0.83 CYP2C9 (0.75) CYP2C9CYP3A4CYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1133474-B1 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS BRISTOL MYERS SQUIBB CO (US) 2007-02-21 EP disclosed
EP-1133474-A4 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS BRISTOL MYERS SQUIBB CO (US) 2005-02-16 EP disclosed
EP-1133474-A1 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-09-19 EP disclosed
US-6184231-B1 NEUROPROTECTANTS; TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, TRAUMATIC BRAIN INJURY, SEXUAL DYSFUNCTION BRISTOL-MYERS SQUIBB 2001-02-06 US disclosed
WO-2000034244-A1 3-SUBSTITUTED-4-ARYLQUINOLIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-06-15 WO disclosed