Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165061 | 0.91 | HDAC1 (0.53) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL5161728 | 0.80 | HDAC1 (0.58) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL4261230 | 0.76 | HDAC2 (0.54) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL4261233 | 0.76 | HDAC2 (0.54) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL14051480 | 0.74 | HDAC1 (0.58) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL5163251 | 0.73 | HDAC1 (0.62) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL4261801 | 0.73 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4261798 | 0.73 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4895649 | 0.72 | HDAC1 (0.56) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL1064696 | 0.71 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |