Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164835 | 0.87 | MAPT (0.77) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL5165966 | 0.84 | MAPT (0.78) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL5165083 | 0.84 | HTT (1.00) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL5160240 | 0.82 | MAPT (1.00) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL5160111 | 0.82 | MAPT (0.75) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL581787 | 0.80 | AR (0.70) | MAPTGAASMN1; SMN2ARLMNA | |
| SCHEMBL5162135 | 0.78 | MAPT (0.68) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL6281157 | 0.78 | MAPT (0.64) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL5163926 | 0.73 | MAPT (0.64) | MAPTGAASMN1; SMN2HTTKMT2A | |
| SCHEMBL6326092 | 0.73 | MAPT (0.61) | MAPTGAASMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231982-B1 | USE OF PHTHALAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ABBOTT GMBH & CO KG (DE) | 2007-03-21 | — | — | EP | disclosed |
| US-6903098-B1 | Use of phthalazine derivatives | ABBOTT GMBH & CO. (DE) | 2005-06-07 | — | — | US | disclosed |