Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.68 |
| ▸ | CDK4 | P11802 | 6/20 | 0.68 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.56 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159474 | 0.81 | CDK2 (1.00) | CDK2CDK4EIF2AK2CDK1CDK7 | |
| SCHEMBL1415012 | 0.80 | CDK2 (0.67) | CDK2CDK4CAMK2DABL1PRKCA | |
| SCHEMBL2283009 | 0.79 | CDK2 (0.83) | CDK2CDK4CAMK2DEIF2AK2ABL1 | |
| SCHEMBL4800928 | 0.77 | CDK2 (0.79) | CDK2CDK4CAMK2DABL1BCR | |
| SCHEMBL6157845 | 0.76 | CDK2 (0.78) | CDK2CDK4ABL1CCNT1CDK1 | |
| SCHEMBL2284099 | 0.76 | CDK2 (0.73) | CDK2CDK4CAMK2DEIF2AK2ABL1 | |
| SCHEMBL2286433 | 0.75 | CDK2 (0.76) | CDK2CDK4CAMK2DEIF2AK2ABL1 | |
| SCHEMBL27741372 | 0.75 | CDK2 (0.76) | CDK2CDK4CAMK2DEIF2AK2ABL1 | |
| SCHEMBL27720262 | 0.75 | CDK2 (0.76) | CDK2CDK4CAMK2DEIF2AK2ABL1 | |
| SCHEMBL4802694 | 0.75 | CDK2 (0.76) | CDK2CDK4CAMK2DEIF2AK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1760082-A1 | N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl)-N-phenylamines as anti-proliferative compounds | Cyclacel Limited (GB) | 2007-03-07 | — | — | EP | disclosed |