Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | POLQ | O75417 | 3/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165191 | 0.84 | KMT2A (0.58) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL5164446 | 0.83 | MEN1 (0.57) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL7721592 | 0.81 | MEN1 (0.46) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL5165920 | 0.81 | HDAC4 (0.61) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL6999935 | 0.81 | HDAC4 (0.63) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL7722456 | 0.79 | HDAC4 (0.39) | MEN1KMT2APGRHDAC4MAP3K5 | |
| SCHEMBL10670006 | 0.79 | KMT2A (0.74) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL7245512 | 0.77 | HDAC4 (0.69) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL5164782 | 0.77 | HDAC4 (0.58) | MEN1KMT2APGRHDAC4SRC | |
| SCHEMBL10678687 | 0.75 | MEN1 (0.68) | MEN1KMT2APGRHDAC4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224172-B1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2007-04-04 | — | — | EP | disclosed |
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |