Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 15/20 | 0.70 |
| ▸ | RPS6KA1 | Q15418 | 15/20 | 0.70 |
| ▸ | AKT2 | P31751 | 14/20 | 0.70 |
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.69 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.68 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.55 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | ULK1 | O75385 | 1/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | SMC2 | O95347 | 1/20 | 0.55 |
| ▸ | LATS1 | O95835 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140881 | 0.91 | AKT1 (0.84) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL4292674 | 0.91 | AKT1 (0.84) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL5140829 | 0.88 | AKT1 (0.66) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL4297241 | 0.85 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL4295253 | 0.85 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| Hydrochloric Acid SCHEMBL4297263 | 0.85 | AKT1 (0.79) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL13702486 | 0.81 | AKT1 (1.00) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL4288241 | 0.80 | AKT1 (0.72) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL4293734 | 0.79 | AKT1 (0.73) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 | |
| SCHEMBL4287860 | 0.78 | AKT1 (0.80) | AKT1ROCK1RPS6KA1AKT2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948185-A2 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007058852-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |