Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163913 | 0.89 | CHEK1 (0.51) | CHEK1KDM4EKMT2AMEN1POLB | |
| SCHEMBL2034828 | 0.85 | KDM4E (0.55) | CHEK1KDM4EKMT2AMEN1POLB | |
| SCHEMBL2037216 | 0.84 | CHEK1 (0.51) | CHEK1KDM4EKMT2AMEN1LRRK2 | |
| SCHEMBL2035058 | 0.81 | LRRK2 (0.51) | CHEK1LRRK2CHEK2IRAK4 | |
| SCHEMBL5163651 | 0.80 | CHEK1 (0.47) | CHEK1KDM4ECHEK2AKT1FECH | |
| SCHEMBL5163297 | 0.80 | CHEK1 (0.51) | CHEK1KDM4EKMT2AMEN1LRRK2 | |
| SCHEMBL2035648 | 0.78 | CHEK1 (0.54) | CHEK1KDM4EKMT2AMEN1LRRK2 | |
| SCHEMBL2035402 | 0.78 | CHEK1 (0.51) | CHEK1KDM4EKMT2AMEN1LRRK2 | |
| SCHEMBL2035693 | 0.77 | BRD4 (0.53) | CHEK1KDM4EKMT2AMEN1POLB | |
| SCHEMBL2035559 | 0.77 | CHEK1 (0.51) | CHEK1KDM4EKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765808-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006012308-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |